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    隋森芳 博士

    教授,博士生導師
    中科院院士

    1964-1970    清華大學精密儀器系,學士

    1978-1981    清華大學工程物理系,碩士

    1985-1988    德國慕尼黑工業大學生物物理所,博士

    1989-1991    清華大學生物科學與技術系,副教授

    1991.1-至今 清華大學生命科學學院(2009年9月以前為生物科學與技術系),教授、博導

     

    ● 研究興趣、領域:

    我們利用冷凍電子顯微學,結合生物化學、生物物理學和細胞生物學等技術手段,研究:

    (1)蛋白質復合體、復雜蛋白質機器和膜蛋白的結構、功能與工作機制;

    (2)囊泡運輸中的分子機制,蛋白質與膜脂的相互作用,生物膜與重大疾病的關系。

    ● 代表性論文:

    1.  Yang X, Yang F, Wang W, Lin G, Hu Z, Han Z, Qi Y, Zhang L, Wang J, Sui SF*, Chai J*. (2018) Structural basis for specific flagellin recognition by the NLR protein NAIP5. Cell Research, 28:35-47.

    2.  Zhang J, Ma J, Liu D, Qin S, Sun S*, Zhao J, Sui SF*. (2017) Structure of phycobilisome from the red alga Griffithsia pacifica. Nature, 551:57-63.

    3.  Sun S, Li L, Yang F, Wang X, Fan F, Yang M, Chen C, Li X, Wang HW, Sui SF*. (2017) Cryo-EM structures of the ATP-bound Vps4-E233Q hexamer and its complex with Vta1 at near-atomic resolution. Nat Commun., 8:16064.

    4.  Zhang L, Wang X, Fan F, Wang HW, Wang J*, Li X*, Sui SF*. (2017) Cryo-EM structure of Nma111p, a unique HtrA protease composed of two protease domains and four PDZ domains. Cell Research, 27:582-585.

    5.  Zhang J, Pan X, Yan K, Sun S, Gao N*, Sui SF*. (2015) Mechanisms of Ribosome Stalling by SecM at Multiple Elongation Steps. eLife, 4: e09684.

    6.  Hu Z, Zhou Q, Zhang C, Fan S, Cheng W, Zhao Y, Shao F, Wang HW, Sui SF*, Chai J*. (2015) Structural and Biochemical Basis for Induced Self-propagation of NLRC4.Science, 350:399-404.

    7.  Chang L, Liu X, Li Y, Liu CC, Yang F, Zhao J*, Sui SF*. (2015) Structural organization of an intact phycobilisome and its association with photosystem II. Cell Research, 25:726-737.

    8.  Zhou Q, Huang X, Sun S, Li X, Wang HW*, Sui SF*. (2015) Cryo-EM structure of SNAP-SNARE assembly in 20S particle. Cell Research, 25:551-560.

    9.  Chang LF, Chen S, Liu CC, Pan X, Jiang J, Bai XC, Xie X, Wang HW, Sui SF*. (2012) Structural characterization of full-length NSF and 20 S particles. Nat Struct Mol Biol., 19:268-275.

    ● 聯系方式:

    電話:+86-10-62792083/62784768

    E-mail: suisf@mail.tsinghua.edu.cn

    Lab website: http://suilab.www.z8328.com/

     

    狠狠撸影院